Dr. Felice Gersh explains how estrogen and progesterone shape brain health, cognition, and longevity — and why hormone loss accelerates aging.

In this episode, I sit down with Dr. Felice Gersh to explore how estrogen and progesterone affect the brain, metabolism, inflammation, and longevity. We unpack why menopause accelerates cognitive aging, how hormone therapy was misunderstood after the Women’s Health Initiative, and why today’s low-dose, daily hormone protocols may fall short. This conversation reframes hormones as essential regulators of brain health across a woman’s lifespan.

Felice Gersh, MD, is a multi-award-winning physician with dual board certifications in OB-GYN and Integrative Medicine. She is the founder and director of the Integrative Medical Group of Irvine, a practice that provides comprehensive health care for women by combining the best evidence-based therapies from conventional, naturopathic, and holistic medicine. For 12 years, she taught obstetrics and gynecology at Keck USC School of Medicine as an Assistant Clinical Professor, and she now serves as an Affiliate Faculty Member at the Fellowship in Integrative Medicine through the University of Arizona School of Medicine.

Dr. Felice is a prolific writer and lecturer who speaks globally on women’s health and regularly publishes in peer-reviewed medical journals. She is the bestselling author of the PCOS SOS series and her latest book, Menopause: 50 Things You Need to Know.

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