In this episode, I sit down with Dr. David Perlmutter to explore the emerging science behind microglia, inflammation, metabolism, and brain aging. We discuss why Alzheimer’s may be driven more by chronic immune activation than beta-amyloid alone, how lifestyle factors shape brain health, and why blood sugar, sleep, stress, exercise, and social connection all matter. Dr. Perlmutter also shares practical ways he protects his own brain health every day.

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Dr. Perlmutter is a Board-Certified Neurologist and five-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition. He received his MD degree from the University of Miami School of Medicine, where he was awarded the Leonard G. Rowntree Research Award. He serves as a member of the Editorial Board for the Journal of Alzheimer’s Disease. He has published extensively in peer-reviewed scientific journals, including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition. In addition, he is a frequent lecturer at symposia sponsored by institutions such as the World Bank and IMF, Columbia University, Scripps Institute, New York University, and Harvard University. He serves as an Associate Professor at the University of Miami Miller School of Medicine.

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