Weight loss and weight maintenance are not the same skill set, and treating them as if they are is one of the biggest reasons so many people lose weight only to regain it. In this episode of the Thrive on Plants Podcast, Dr. Daphne Bascom sits down with Dr. Holly Wyatt and Dr. James Hill to unpack what actually changes in your body, brain, and environment when you lose weight, why maintenance is harder, and how to build a plant‑powered life that supports long‑term success at any age.

IN THIS EPISODE, WE COVER:

Why GLP‑1 medications (like semaglutide and similar drugs) work so well for weight loss, and why stopping them often triggers rapid regain if you do not have a maintenance plan in place.
The difference between weight loss and weight maintenance, including how metabolic adaptation, set point, and muscle loss can work against you, especially in midlife.
The 3 pillars of long‑term success: food (resetting appetite naturally on a whole‑food, plant‑based pattern), movement (how much and what kind protects weight loss and muscle), and mindstate (the daily mental “state” that separates short‑term success from sustainable change).
How perimenopause and menopause change metabolism, body composition, and appetite signals, and what midlife women can do to protect lean mass and metabolic health with or without GLP‑1s.
The three maintenance profiles (food seeker, sedentary sitter, setback cycler) and how to tailor your strategy based on where you see yourself.

If you want to learn how to stop weight-loss meds without regaining, this conversation offers evidence‑based, compassionate guidance you can put into practice today.

Resources

Dr. Holly Wyatt & Dr. James Hill

Book, “Losing the Weight Loss Meds”: https://www.amazon.com/dp/1637747802?ref=ppx_yo2ov_dt_b_fed_asin_title
Website: https://www.weightlossand.com/
Website: https://www.weightwisdom.com/
“Weight Loss and…” podcast on Apple: https://podcasts.apple.com/us/podcast/weight-loss-and/id1723878862

Key research referenced:

SURMOUNT‑4 trial on stopping meds and cardiometabolic health: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2841273

Additional resources to help you thrive on plants:

🌱 Access the free Plant-Powered Body course: Access Here

🌱 Take the free health assessment for women 40+: Start Here

🌱 Watch every episode on YouTube

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#46 - Weight Loss vs Weight Maintenance: Lessons from 10,000 People Who Kept It Off