At Euroanaesthesia in Rotterdam, TopMedTalk hosts Andy Cumpsty and Kate Leslie speak with Denise Veelo Professor of Anesthesiology at the Amsterdam University Medical Center and Bernd Saugel Professor of Anesthesiology and Vice Chair of the Department of Anesthesiology in the Center of Anesthesiology and Intensive Care Medicine at the University Medical Center Hamburg-Eppendorf, about two JAMA blood-pressure trials published on the same day.

Veelo describes a 3,500-patient, two-center randomized trial comparing usual care (MAP 65) with more intensive, risk-stratified higher MAP thresholds (70/80/90) using a functional recovery primary outcome, stopped early for futility. Saugel outlines the 1,300-patient IMPROVE trial in 15 German centers, individualizing the lower intervention threshold to each patient's preoperative nighttime MAP versus routine MAP 65, with a 7-day composite outcome; no significant difference was found and event rates were ~30%.

They conclude routine targeting substantially above MAP 65 is not supported for broad populations, note special circumstances may differ, and they discuss limitations, vasopressor-heavy practice, and future research including the ASPIRE 85 delirium-focused trial and work on autoregulation and physiology.

The 2026 International Practicum on Cardiopulmonary Exercise Testing will be held at the Balmer Lawn Hotel in Brockenhurst, UK, from September 16th to 18th this year. It is organised by iPOETTS , the international perioperative testing and training society.

Come and join us at this premier educational event designed for clinicians, scientists, and healthcare professionals interested in sport, exercise, and perioperative medicine.

This is an International Perioperative Testing and Training Society accredited event so when you attend you can get your iPOETTS accreditation, showing that you are a practitioner who has reached a high, standardized level of competence in performing and interpreting Cardiopulmonary Exercise Testing (CPET) for patients preparing for major surgery.

Go now to http://www.ebpom.org