Podcast
Peptide of The Week
Hosted by JD Denham and Will Haas · EN
Hosted by JD Denham and Will Haas, The Peptide of The Week Podcastis your no-BS guide to peptides, performance, and total body optimization. Whether you’re an athlete, a high performer, or just hungry to feel better, move better, and live stronger this show’s for you. JD and Will dive deep into real-world protocols, hard-earned lessons, and the science behind what actually works. With expert guests and raw conversations, you’ll get everything from cutting-edge peptide talk to diet, training, recovery, and mindset. No fluff. No filters. Just the tools to rebuild your body and upgrade your life.
23episodes
Episodes
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Peptide Q&A #42 – Starting in Peptides, Peptides for dogs, Skin Pigment Changes & Type 1 Diabetes
2d ago01:00:02Tap to summarizeMedical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover how to get started in the peptide space, skin pigment changes from GH peptides, peptide protocols for Type 1 diabetes, endometriosis, old chronic injuries, and yes peptides for your dog.Chapters:00:00 – Intro & Vegas Plans02:20 – How Business Success Really Happens06:24 – Discipline, Purpose & The Warrior Gene11:20 – Gratitude for the Audience12:57 – How to Start in Peptides19:08 – Best Resources to Learn Peptides22:32 – Why Peptides Are Exploding24:21 – IGF-1, Ipamorelin & Skin Pigmentation27:16 – Type 1 Diabetes & Peptide Recommendations31:43 – Fat Loss, Muscle Growth & GLP-1 Strategy36:48 – Cardiovascular Health & Statin Alternatives41:37 – Healing Chronic Injuries with Peptides47:47 – Mixing Peptides in One Syringe52:40 – Endometriosis, Autoimmune & Inflammation55:35 – Peptides for Dogs & Joint Health58:58 – Outro & Upcoming EpisodesWe cover:• How to Get Started in the Peptide Space: Why an RN license helps, why the research-only space has limits, and how white-labeling and deep studying are the real entry points• Best Resources for Learning Peptides: Why PubMed beats any book, how Jay Campbell's work holds up, and why self-experimentation is irreplaceable• Skin Pigment Changes on GH Peptides: Why higher GH levels can affect melanin, what Melanotan 2 symptoms look like, and why switching to real HGH may be the cleaner move• Peptides for Type 1 Diabetes: Why secretagogues and GLPs carry real risk, and which peptides like AOD, BPC, NAD and SS-31 are safer options• Dropping Tirzepatide for Retatrutide: How to taper down half a milligram at a time and why staying under four migs of Reta is the sweet spot• Statins vs. Peptides for ApoB: Why diet and fasting outperform any peptide here, and where Cardiogen, BPC and Reta offer cardiovascular support• Wolverine Stack for Old Chronic Injuries: Why TB-500 is the key compound for dormant injuries, how GHK-CU supports nerve healing, and why movement matters as much as the peptide• Mixing Peptides in One Syringe: What to never combine, why AOD needs its own water, and when HGH and GLPs should always stay separate• Endometriosis & Hashimoto's Protocol: Why KPV and TA-1 are right, the role of LL-37 at micro doses, and why VIP helps flush the Herxheimer reaction• Peptides for Your Dog's Bad Hips: Why BPC and TB-500 work on canines, how to dose by weight, and why injecting right at the hips is the best approach📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.You're a warrior. Act like one.Follow us on social media:JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Join The Community: https://www.skool.com/peptideresearchinstitute/about
Transcribe →Peptide of the Week: Autoimmune, Gut Health & GLP-1s – With Paul Bakhtiar
5d ago01:07:09Tap to summarizeMedical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas are joined by returning fan favorite Paul Bakhtiar peptide Jedi and clinical consultant for a deep dive into autoimmune disorders, gut health, GLP-1 optimization, and protocols working in real clinical settings.Chapters:00:00 – Intro & Mixing Peptides Debate04:44 – Peptides for Recovery & Inflammation09:31 – Autoimmune Disorders Explained15:30 – Thymalin, TA1 & Immune Function18:38 – LL-37, VIP & Pathogen Response23:13 – Crohn’s, Hashimoto’s & Gut Health27:06 – BPC-157, Angiogenesis & Healing32:19 – Surgery Recovery & Peptide Protocols33:01 – Vitiligo, Psoriasis & Skin Healing35:35 – Folliculitis, Leaky Gut & Carnivore41:10 – Toxins, Sauna & Detoxification46:04 – GLP-1s, Inflammation & Neuroprotection52:04 – Estrogen, TRT & Bloodwork Optimization56:44 – SS-31, MOTS-C & Neuropathy RecoveryWe cover:🧬 What's happening in autoimmune disorders– Body attacks itself — thyroid in Hashimoto's, gut in Crohn's, skin in psoriasis– 80% of diagnosed autoimmune disorders occur in women– Root cause is almost always the gut — fix the gut, everything follows– Antibiotics, processed food, seed oils, stress, and poor sleep are the biggest culprits🛡️ Master Autoimmune Protocol (Psoriasis, Lupus, Lyme, MS)– Thymalin: re-educates immune system — the marathon (5–10mg, 10 days straight)– Thymosin Alpha-1 (TA-1): quick sprint to boost T cells (1.5mg, 3x/week, 6–8 weeks)– Run both together– LL-37: penetrates biofilm, dumps pathogens — 125mcg for 50 days– ⚠️ Don't start LL-37 too early — triggers Herxheimer reaction– VIP: cleans up after LL-37 — start 100mcg 3x/week, build to 200mcg– Always anchor with KPV + BPC-157🦠 Crohn's & Colitis Protocol– KPV + BPC-157 orally first — straight to the source– Add Thymalin + TA-1 simultaneously– Bring in LL-37 if not responding, follow with VIP, then MoTC– Support stack: Glutathione + NAC + L-Glutamine🦋 Hashimoto's Protocol– Same immune foundation: TA-1, Thymalin, KPV, BPC-157 + MoTC– Once markers trend down — add GH peptides (Tesmorelin or CJC + Ipamorelin) for muscle wasting– Monitor insulin, thyroid levels, and autoimmune markers before adding GH axis🧫 SS-31 vs MoTC– SS-31 first: repairs the engine– MoTC second: press the gas– SS-31 also powerful for kidney repair, neuropathy, and heart health🔬 ARA-290– Derivative of EPO — no blood doping effects– Exceptional for neuropathy and nerve regeneration– Pairs well with SS-31💉 GLP-1 Optimization– Reta: Paul hasn't seen anyone need to exceed 8mg– Plateaued on tirzepatide or sema? Titrate down while titrating Reta up– Clinical tip: GLP-1 on Monday → add small CAG dose by Thursday to quiet food noise– GLP-1s are neuroprotective — control glucose to the brain, help prevent Type 3 Diabetes (Alzheimer's, Parkinson's, dementia)💡 Real Talk– No peptide protocol doesn't benefit from BPC-157– Sauna 3x/week at 150–160°F for 20 min is one of the best detox tools available– The compounds work. The lifestyle makes them extraordinary.🧪 This isn't theory this is real-world experience working with hundreds of people and seeing what actually works.📺 Subscribe for more no-fluff peptide education every week.Follow us on social media:JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Paul's Instagram: https://www.instagram.com/paulbakhtiar/Join The Community: https://www.skool.com/peptideresearchinstitute/about
Transcribe →Peptide Q&A #41 – Peptide Blends, Injury Protocols, Carrier Oils & Tesamorelin Storage
1w ago01:22:00Tap to summarizeMedical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover low testosterone at 32, post-surgery wound healing, switching GLPs, peptide blend dosing math, carrier oils for testosterone, and how to properly store Tesamorelin.Chapters:00:00 – Intro & Wedding Weekend Recap05:21 – Traveling, Kids & Family Life11:06 – TRT, RETA & Fat Loss Questions19:18 – Wolverine Stack & Healing Protocols23:57 – Weight Loss, HGH & Recovery31:01 – Arthritis, Injuries & Joint Healing38:20 – Women’s Fat Loss & Hormone Support45:50 – Mixing GLP-1s & RETA Questions49:26 – Fat Loss, Longevity & Busy Moms56:02 – Peptide Blend Dosing Explained01:01:04 – Testosterone Carrier Oils ExplainedWe cover:• Low Testosterone at 32: Why 369 total T is a 60-year-old's number, what a full hormone panel should include, and why TRT isn't a life sentence• Post-Surgery Wound Healing: Why BPC, TB-500 and KPV at high doses beats the Wolverine blend for open incisions and when to add the serum• Back Injury Dosing: When to run a loading phase vs. maintenance, why resting matters as much as the peptide, and how to identify structural vs. tissue injuries• Retired NYPD with Arthritis & Tendonitis: Why aggressive Wolverine dosing, Thymosin Alpha-1, and HGH are the right protocol for chronic job-related injuries• Can You Stack Two GLP-1s?: Why you don't need to and why Retatrutide does everything Tirzepatide does but better• Fat Loss Stack for Active Mom: Why Tesamorelin, NAD, GHK-CU, SLU-PP-332 and creatine covers all goals with minimal injections• 37-Year-Old Female Physique Goals: Why PT-141, Tesamorelin/Ipa blend, NAD, Tesofensine and C-Max/C-Long hit every target from fat loss to sex drive• Peptide Blend Dosing Math Explained: How to calculate exact milligrams per unit for any blend using simple division — no guesswork• Carrier Oils for Testosterone: MCT vs. grape seed vs. cottonseed vs. castor oil, what Miglyol 840 actually is, and why concentration matters more than the oil itself• Tesamorelin Storage After Mixing: Why room temp water and a cool dark place beats the fridge, and how to buy the right vial size so nothing goes to waste📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.You're a warrior. Act like one.Follow us on social media:JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Join The Community: https://www.skool.com/peptideresearchinstitute/about
Transcribe →Peptide of the Week: KPV & PT-141 – Gut Health, Inflammation & Libido
2w ago00:38:54Tap to summarizeMedical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down two peptides that are more connected than you'd think KPV for inflammation and gut health, and PT-141 for libido and arousal. One calms the fire inside, the other lights a different kind of fire.Chapters:00:00 Intro00:09 Welcome & Banter (Myrtle Beach, Sharks)03:23 Today's Topics Overview05:55 KPV: What It Is & How It Works08:06 KPV vs NSAIDs – Targeted Inflammation09:00 KPV for Gut Health & Stacking with BPC15:00 Stress, Cortisol & Body Composition20:25 Peptides vs Western Medicine21:26 KPV Real Life Results25:43 PT-141: Introduction26:14 How PT-141 Was Discovered27:21 PT-141 vs Viagra/Cialis36:22 PT-141 Dosing Tips & Final Thoughts37:49 OutroWe cover:🧬 What is KPV?– A tri-peptide (just 3 amino acids) derived from alpha-MSH — the same hormone PT-141 comes from– Your body naturally produces it — virtually zero side effect profile– Selectively targets inflammation rather than shutting it all off like NSAIDs– Calms cytokine storms and autoimmune responses without killing good inflammation– Works in tandem with BPC-157 — KPV calms the environment, BPC does the tissue repair🔥 What KPV actually treats– Crohn's disease, ulcerative colitis, microscopic colitis, IBS, leaky gut– Inflammatory skin conditions — eczema, psoriasis, rosacea, chronic acne– Post-antibiotic gut damage — if you ran antibiotics, run KPV– Athletes overtraining — reduces chronic inflammation that slows recovery past 48 hours– Any autoimmune condition driven by gut dysfunction⚠️ The cortisol connection– Stress, poor sleep, alcohol, and travel all spike cortisol — your body's fight-or-flight hormone– Cortisol breaks muscle down, converts it to sugar, and stores fat right at the belly button– Less than 5 hours of sleep = no fat burning, no muscle building all day long– Alcohol keeps your body out of fat-burning mode until 2–3 PM the next day– KPV helps combat the inflammatory cascade that chronic cortisol creates🔥 What is PT-141?– Also derived from alpha-MSH — same origin as KPV, completely different job– Discovered accidentally in the 1980s at University of Arizona during tanning research — men started getting spontaneous erections– FDA approved in 2019 for hypoactive sexual desire disorder in post-menopausal women– Works on the BRAIN — not blood vessels like Viagra or Cialis– Boosts dopamine = increases desire, motivation, and arousal from the inside out– Works equally well for men AND women💡 How it feels (real-world experience)– Kicks in 45 minutes after injection– Flushing/redness right after injection is normal– Arousal builds gradually — touch or kissing accelerates the effect significantly– Hypersensitivity during the act– Too much = nausea, elevated blood pressure, feeling "off" — find your dose– JD's experience at 2mg: incredible night, felt like a 16-year-old all the next day — too much⚠️ What to watch with PT-141– Can raise blood pressure at higher doses — monitor if sensitive– Nausea is common, especially early on — usually a quick wave that passes– Do NOT take with uncontrolled hypertension– Don't combine with other vasodilators carelessly🧪 This isn't theory this is real-world experience working with hundreds of people and seeing what actually works.📺 Subscribe for more no-fluff peptide education every week.Follow us on social media:JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Join The Community: https://www.skool.com/peptideresearchinstitute/about
Transcribe →Peptide Q&A #40 - Traveling With Peptides, Tirzepatide vs. Retatrutide & Bacteriostatic Water Facts
2w ago01:04:29Tap to summarizeMedical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover bacteriostatic water shelf life, traveling with peptides, fixing chronic injuries, why Clenbuterol is outdated, and when to switch from Tirzepatide to Retatrutide.Chapters:00:00 – Intro & Parenting Talk07:59 – Warrior Makers Meetup & School Update10:06 – Bacteriostatic Water & AOD Discussion15:28 – PNC-27, Cancer & Fasting21:06 – Back Injury, Wolverine & Healing26:10 – Loose Skin, GHK-CU & Fat Loss30:43 – Traveling with Peptides & Retatrutide38:26 – Sleep, Brain Fog & Recovery43:26 – TRT, HGH & Fat Loss Stack47:48 – Anavar, Clenbuterol & Cutting52:15 – HGH, Tesa & Long-Term Protocols56:32 – Tendonitis, Recovery & Wolverine Dosing1:00:47 – Weight Loss Plateau & RetatrutideWe cover:• Bacteriostatic Water — The Real 28-Day Rule: What actually happens after 28 days and why bottle size affects your timeline• AOD-9604 After 13 Weeks: Why it's time to rotate and what SLU-PP-332 and 5-Amino-1-MQ can replace it with• PNC-27 for Cancer Prevention: What the science says and why fasting may still be the smarter proactive move• Back Injury at Night, Fine During Day: When BPC + TB-500 help vs. when it's a structural issue requiring higher doses• Loose Skin After Major Fat Loss: Why GHK-CU beats Snap-8 for collagen remodeling and why HGH is the real game changer• Traveling With Peptides: Check your bag, use a peptide case, travel unmixed, and why syringes cause more headaches than peptides• Switching From Tirzepatide to Retatrutide: Why poor appetite is a side effect not a goal and why you don't need to wait 14 days• Sleep Protocol That Actually Worked: Magnesium glycinate, glycine, ashwagandha, time-release melatonin and Epithalon for circadian reset• Anavar vs. Clenbuterol: Why Clen is largely outdated and why high-dose SLU-PP-332 or Retatrutide does it cleaner• HGH Plus Tesamorelin — Does It Make Sense?: Why Tessa still burns belly fat even when HGH suppresses pituitary signaling• Chronic Heel Tendonitis Protocol: Why two years of injury needs a heavy loading blast and why rest matters just as much📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.You're a warrior. Act like one.Follow us on social media:JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Join The Community: https://www.skool.com/peptideresearchinstitute/about
Transcribe →Peptide of the Week: Hair Restoration & Longevity Medicine – With Dr. Sam Borghei & Todd Padberg
3w ago00:57:15Tap to summarizeMedical Disclaimer: We are not doctors. This content is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas are joined by Dr. Sam Borghei 20-year ER physician and owner of My Hair MD and Todd Padberg, General Manager of My Hair MD. We dig into hair restoration, natural-looking results, peptides for recovery, and the future of medicine.Chapters:00:00 – Intro & Guest Introduction03:18 – ER Life, Stress & Burnout06:14 – Personality Traits of ER Doctors10:08 – Transition Out of ER12:16 – Hair Transplant Process Explained18:04 – Procedure, Recovery & Limitations23:02 – Industry Trends & Patient Demand25:55 – Recovery, Peptides & Healing29:41 – Cost Breakdown & Expectations34:23 – Preventative Medicine & Telehealth Vision38:57 – Trust in Medicine Post-COVID43:12 – Peptides, Research & Future Outlook49:00 – Fitness, Hormones & Lifestyle54:54 – Contact Info & OutroWe cover:🧬 Who is Sam Borghei? 20+ years in frontline ER medicine. Now owner of My Hair MD in San Diego and building a telehealth longevity platform focused on hormone optimization, weight loss, and personalized wellness.✂️ How a hair transplant works FUE method: follicles are individually extracted from the DHT-resistant donor zone (back of the head). A 3,000–3,500 graft procedure involves 10,500+ steps over 6–8 hours. Grafts are sorted by size heavy grafts go to the back, singles go up front for a natural hairline. Those donor follicles do NOT grow back you have a finite supply (6,000–10,000 max).🎨 The art of a natural result Hairlines are drawn jagged on purpose. Single hairs line the very front, temples are always filled in, and age-appropriate design matters. Artistry makes all the difference.💉 Peptides & hair recovery Will used BPC-157, TB-500, and GHK-Cu shampoo post-transplant. BPC-157 and TB-500 support angiogenesis and blood flow to follicles. GHK-Cu supports collagen production and scalp stabilization. Will's results were fast with minimal shedding. PRP and laser light therapy are also available at My Hair MD.💊 Medications that protect your transplant Dutasteride blocks DHT (which miniaturizes and kills follicles). Minoxidil increases blood flow to support graft survival. Both are commonly used alongside transplants.💡 Pricing FUE: ~$3.50/graft | FUT strip: ~$3.00/graft. All-inclusive, no hidden fees, financing available. Online consultations offered. Contact Todd: todd@myhairmd.com🩺 Where medicine is heading Dr. Borghei's telehealth platform (Summer) offers personalized longevity plans biomarker monitoring, hormone optimization, weight loss, and hair restoration. His take: medicine is not one-size-fits-all, and the patient-physician relationship needs to come back.🧠 Real talk on peptides Peptides are chains of amino acids with a remarkably low risk profile compared to many pharmaceuticals. FDA classifications are shifting, research is coming, and early adopters are already seeing results.Follow for more:My Hair MD: myhairmd.com | todd@myhairmd.com JD's IG: @jd_denham_fit | Will's IG: @williamthaas | Community: skool.com/peptideresearchinstitute
Transcribe →Peptide Q&A #39 – The Full GH Peptide Breakdown, IGF-1 LR3 Protocols, with Paul Bakhtiar
3w ago01:22:16Tap to summarizeMedical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas sit down with returning guest Paul Bakhtiar president of telehealth for one of the largest peptide manufacturers in the country and keynote speaker at major peptide conferences for a deep dive into the entire growth hormone peptide category, IGF-1 LR3 protocols, how to stack without overlapping pathways, male fertility, and much more.Chapters:00:00 – Intro to Peptides & Telehealth06:01 – Growth Hormone Overview11:50 – Timing & Dosing Peptides18:04 – AOD 9604 & Fat Loss25:55 – Optimizing GH & Bloodwork30:23 – GH Peptides Breakdown (Tesa, CJC, Sermorelin)35:40 – Peptide Blends & Side Effects44:29 – HGH Risks, Legality & Hormones51:21 – Slu-PP-332 & Fat Loss54:11 – Fasting, Cancer & Healing (BPC-157)1:01:41 – NAD+, Protocols & Final TakeawaysWe cover:• Mixing Multiple Peptides in One Syringe: Why it's safe, how to do it right, and why you don't need to be a pin cushion• The Full GH Peptide Hierarchy Explained: HGH vs. secretagogues vs. IGF-1 LR3 — what replaces, stimulates, and bypasses your natural growth hormone and when to use each• IGF-1 LR3 Timing, Dosing & Cycle Length: Pre- vs. post-workout debate, why 20–40 mcg is the sweet spot, and why four to six weeks on with equal time off is the smart approach• Tesamorelin vs. Sermorelin vs. CJC-1295: Strength rankings, dosing protocols, pituitary vs. blood plasma signaling, and why Tessa is Paul's top pick• Ipamorelin Ratios for Women: Why equal blends can cause water retention and the case for keeping Ipa lower relative to Tessa or CJC• IGF-1 Sweet Spot on Blood Work: Why 250–350 is the optimal range for fat loss, lean muscle, sleep quality, and cognitive function• AOD-9604 & SLU-PP-332 Fat Loss Protocols: Proper AOD dosing, fasted cardio timing, and what the latest sloop studies show at higher milligram doses• SS-31 Then MOTS-C for Mitochondrial Health: How to sequence them, the loading and maintenance phase for metabolic damage, and managing histamine reactions• NAD+ Dosing Done Right — and What Happens When You Overdo It: Why 200mg per week is the sweet spot and what happens when you accidentally take 500mg• Optimal Blood Work Markers for Testosterone: Total, free, DHEA, and SHBG targets for men and women — and why DHEA is a $25 fix most people overlook• Male Fertility Protocol: HCG dosing, HMG every other day, N-clomiphene citrate, and why Paul avoids standard clomid• BPC-157, Angiogenesis & Cancer Research: What the latest rat model studies show about wound healing vs. chaotic angiogenesis and why the risk conversation is shifting📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.You're a warrior. Act like one.Follow Paul Bakhtiar:Instagram: https://www.instagram.com/paulbakhtiar/His Links: https://thepeptidepro.co/linktreeFollow us on social media:JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Join The Community: https://www.skool.com/peptideresearchinstitute/about
Transcribe →Peptide of the Week: NAD+ & Tesofensine: Anti-Aging and Brain-Based Weight Loss Explained
4w ago00:58:33Tap to summarizeMedical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! JD Denham and William T. Haas break down two powerhouse compounds NAD+ and Tesofensine covering what they are, how they work, real-world experience, and how to dose them right.Chapters:00:00 – Intro & Life Updates05:30 – Parenting, Discipline & Boys10:00 – Family, Values & Growth18:30 – NAD Explained (What It Does)25:30 – NAD Benefits & Real Results29:00 – NAD Dosing & Side Effects37:45 – NAD Cycles & Best Use38:15 – Tesofensine Breakdown42:00 – Energy, Focus & Fat Loss Effects48:30 – Who Should (and Shouldn’t) Use It52:30 – Dosing, Side Effects & Warnings55:30 – School Platform & What’s Next57:45 – Outro🧬 What is NAD+? A coenzyme found in every cell in your body — essential for life. Powers over 500 enzymatic reactions and is critical for ATP (cellular energy) production. Declines dramatically with age: 100% at birth → 55% by age 40 → 34% by age 60. That decline is why we age — cells stop repairing and regenerating as well.🔥 What NAD+ actually does – DNA and cellular repair — slows aging at the genetic level – Boosts natural cellular energy (not stimulant energy) – Neuroprotective — mental clarity, sharper focus, better brain function – Improves insulin sensitivity, lipid regulation, and cardiovascular function – Regulates inflammatory pathways and immune response🧠 What is Tesofensine? A triple reuptake inhibitor (serotonin + dopamine + norepinephrine). Originally developed for Alzheimer's and Parkinson's — researchers noticed patients losing massive amounts of weight. Clinical trials showed 9–11% average body weight loss over 24 weeks.⚖️ How Tesofensine works – Targets the brain — makes food stop giving you a dopamine hit – Reduces cravings for sweets and junk without fully suppressing hunger like GLP-1s – Does NOT spike blood sugar during fasting – Real energy increase — dopamine-driven motivation, not jittery stimulant energy – Great GLP-1 transition compound for weaning off without falling off track💡 Real-world experience JD's first run felt off and tired — gave it a bad rep initially. Second run (last 3 weeks): loves the focused, clean energy, similar to Modafinil. Will: no more naps, more motivated, doesn't want to miss the day. Both agree — take it in the first half of the day, it will keep you up.⚠️ What to avoid – Do NOT combine with SSRIs, SNRIs, or NDRIs (Zoloft, Wellbutrin, etc.) – Reduce caffeine — unnecessary stimulant overload – Do NOT combine with Modafinil – Not recommended for uncontrolled hypertension, bipolar disorder, or severe anxiety – Monitor blood pressure and run regular bloodwork📺 Subscribe for more no-fluff peptide education every week.Follow us on social media:JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Join The Community: https://www.skool.com/peptideoftheweekcommunity/about
Transcribe →Peptide Q&A #38 – Peptide Testing & Quality Control, HGH for Women & Post-Menopause Weight Loss
Apr 2301:18:59Tap to summarizeMedical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas break down why peptide companies skip advanced testing, how to stack IGF-1 LR3 without overdoing growth pathways, HGH safety for women post-menopause, fixing dangerously low testosterone at 28, and when to pull back Retatrutide and start TRT.Chapters:00:00 – Intro & Podcast Catch-Up11:13 – Peptide Testing & Quality Concerns20:16 – IGF-1, HGH & Stack Overlap29:20 – Women’s Hormones & Hysterectomy32:15 – Menopause, Weight Gain & Peptides44:16 – Peptide Storage & Shelf Life49:44 – NAD+ Crystallization Explained51:37 – Growth Hormones for Women (Age 44)59:44 – Low Testosterone & Mental Health (Age 28)1:05:48 – Building Muscle Without Steroids (Athlete Q&A)We cover:• Why Peptide Companies Don't Test for Endotoxins & Heavy Metals: The real cost breakdown, why cheap peptides come with trade-offs, and how quality standards are rising• Kisspeptin on TRT — Why It Won't Work: How TRT shuts down the signal kisspeptin needs and why HCG is the smarter choice for testicular health on cycle• IGF-1 LR3 Stacking Rules: Why combining HGH, secretagogues, and IGF-1 all at once is too much on the same pathway — and how to rotate smarter• Peptide Shelf Life & Storage Explained: Bacteriostatic vs. sterile water, why HGH is especially sensitive, and the practical rule of thumb for reconstituted peptides• What Causes NAD+ to Crystallize: Dilution ratios, the importance of amber vials, and how to troubleshoot this common issue• Kisspeptin After Hysterectomy: Why it likely won't work without the ovaries and why direct hormone replacement is the better path forward• HGH Safety for Post-Menopausal Women: Addressing 50 pounds of menopause weight gain, why 1 IU of HGH beats secretagogues at this stage, and peptides that target brain fog, mood, skin, and libido• CJC vs. Tesamorelin for Women with Water Retention: Why switching to Tessa and adding AOD is the cleaner approach when CJC causes uncomfortable fluid retention• Low Testosterone at 28 — Fix That First: Why 315 total and 15 free testosterone explains SSRIs, brain fog, depression, and low energy better than anything else• Building Lean Muscle for a Rugby Athlete Without Steroids: Why SLU-PP-332, Cardarine, creatine, and smart fasting are the right tools at 26• BPC-157 Subcutaneous vs. Local Injection for Back Injuries: Why abdominal sub-q still works systemically and how BPC + TB-500 rebuild connective tissue post-dislocation• When to Start TRT & HGH Mid Weight Loss Journey: Why 51 with 35 pounds already lost is the perfect time — and how to wean Retatrutide down the right way📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.You're a warrior. Act like one.Follow us on social media:JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Join The Community: https://www.skool.com/peptideoftheweekcommunity/about
Transcribe →Peptide of the Week: HGH Frag 176-191 vs AOD 9604 – The Fat Burning Fragments Explained
Apr 2000:32:55Tap to summarizeMedical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down two of the most underrated fat-burning peptides out there — HGH Fragment 176-191 and AOD 9604 what makes them different, how to use them, and why they deserve a spot in your cutting stack.Chapters:00:00 – Intro & Marriage / Work Balance10:30 – AOD 9604 vs HGH Frag Intro14:29 – AOD Origins & Fat Loss Benefits19:13 – Half-Life, Dosing & How It Works24:11 – School Community & Membership Update27:05 – Which Is Better: AOD or Frag?29:00 – Why Real Experience Matters29:54 – Company Growth & What’s Next31:13 – Hair Transplant Guest Preview31:58 – Doctors Finally Talking Peptides32:32 – Final Thoughts & OutroWe cover:🧬 What these peptides actually are– Both are fragments of the full 191 amino acid HGH chain– HGH Frag 176-191 = the natural amino acid sequence (176–191)– AOD 9604 = lab-engineered version (177–191), modified for longer duration and better safety profile– AOD received FDA GRAS (Generally Recognized As Safe) status in 2014– Developed at Monash University in Australia 🇦🇺🔥 What they do (and what they don't)– Target lipolysis — fat burning, especially visceral/abdominal fat– Boost metabolism and increase energy expenditure– No IGF-1 spike– No hypoglycemia risk– No effect on growth — zero cancer concern– 30–50% greater fat reduction vs controls in studies– Obese participants lost significantly more body fat vs placebo over 12 weeks⚖️ HGH Frag 176-191– Natural fragment of the HGH chain– Half-life: ~30 minutes– Can dose 1–2x daily (some go 3x)– Best taken fasted — morning or pre-workout– Cycle length: 8–12 weeks– Comes in 5mg bottles (they don't like water — keep it small)👑 AOD 9604– Lab-engineered, modified for longer stability– Half-life: 30–60 minutes– Daily dosing (can split AM/PM)– Additional benefit: potential cartilage and joint repair (not seen with HGH Frag)– Cycle length: 12–16 weeks– FDA GRAS status — one of the safest peptides available– JD's personal top 5 — shines brightest stacked with other cutting compounds🚫 What NOT to combine– High-dose corticosteroids– Full-dose HGH (defeats the purpose of the targeted safety advantage)– Insulin (just don't)✅ What pairs great with these– GLP-1 agonists (Semaglutide, Tirzepatide)– 5-Amino-1MQ– L-Carnitine– BPC-157 + TB-500 (especially with AOD for joint/cartilage synergy)– CJC + Ipamorelin (boosts metabolism and fat burning further)🧠 Real-world take– AOD shines brightest when stacked — it's a force multiplier for your cutting stack– HGH Frag works fast and hits hard on a short half-life– Both are tools — results depend on diet, training, and what you stack them with– Individual response varies — don't let your gym bro's experience dictate yours🔑 Bottom line: If you want pure fat burning with virtually zero downsides, these two are as clean as it gets.🧪 This isn't theory this is real-world experience working with hundreds of people and seeing what actually works.📺 Subscribe for more no-fluff peptide education every week.Follow us on social media:JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Join Our Community: https://www.skool.com/peptideresearchinstitute/about
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